Bioinformatics Methods

NCBIís Database for Annotation,Visualization and Integrated Discovery (DAVID 2.0) was used as the standard source for gene annotation information. The primary fields extracted from DAVID include: locus link, gene symbol, and gene summary. Additional annotations include gene product mappings to the Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology Consortium (GO) for pathway and GO terms/classes, respectively. For Affymetrix arrays, queries were based on the Affymetrix probe ID (AFFYID). For other arrays, the Genbank Accession (GENBANK) was used.

The combined gene annotation information for the Stanley Genomics database includes: