Brain Collection

The database is derived from two sets of brain samples, the Stanley Array collection and the Stanley Consortium collection.
The two collections are described in more detail here.
The Stanley Array collection contains 105 patients, and the Stanley Consortium collection contains 60 patients.

Multiple genomic studies have been conducted using these brain samples. From these studies, twelve were selected for inclusion in the database on the basis of number of patients studied, genomic platform used, and data quality. The Consortium collection studies have fewer patients but more diversity in brain regions and array platforms, while the Array collection studies are more homogenous. There are tradeoffs, the Consortium results will be more variable, but findings may be more broadly representative.

The collections contain brain samples from subjects in four main groups:

Brain regions used in the studies include:

The 12 studies encompass a range of microarray platforms:

Platform Studies Probes Total Samples
Affymetrix HG-U95Av2 3 12,000 193
Affymetrix HG-U133A 4 22,000 373
Affymetrix HG-U133 2.0+ 2 54,000 113
Codelink Human 20K 1 20,000 95
Agilent Human I 1 15,000 100
Custom cDNA 1 16,000 105