Individual Study Disease Analysis

For each study, after removing outliers (see QC section), each of 23 demographic effects was assessed (see demographics section) on a gene-by-gene basis. We recorded which demographics were significant for each gene, where significance was defined as p<.01, FC>1.3. Each disease analysis (bipolar, depression, schizophrenia) was then performed using a regression analysis on a gene-by-gene basis, adjusting for the demographic terms that met the criteria for significance for that gene. Diseases were analyzed using separate regression models.

The ‘Top Regulated Genes’ for each disease were those that met the following criteria: The ‘Additional Regulated Genes’ for each disease met these criteria: